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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10090/4932
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| Title: | Effects of Selective Myostatin Inhibitor PAH-A on Broiler Skeletal Muscle Production |
| Authors: | Snider, Brittany |
| Issue Date: | 2008 |
| Publisher: | Kalamazoo, Mich. : Kalamazoo College. |
| Abstract: | A fivefold increase in worldwide meat production over the past 50 years has
fueled research in muscle physiology toward the development of methods to increase
skeletal muscle growth in agricultural animals. A breakthrough in the exploration of
muscle production occurred in 1997 with the identification of myostatin, a negative
regulator for skeletal muscle development.
Mutations in the myostatin gene have been shown to increase skeletal muscle
growth in several species including mice, cattle, and humans. A natural mutation in
this gene results in the double muscling phenotype of Belgian Blue cattle (Figure 1).
Some strategies proven to repress myostatin function, such as the administration of
myostatin-specific antibodies or the use of a soluble activin type II receptor (ActRIIBFc),
reduce the binding affinity of myostatin to its receptor, activin receptor type II B
(ActRIIB). Pfizer Animal Health Compound A (PAH-A), a selective myostatin
inhibitor, also impedes the attachment of myostatin to ActRIIB.
The effectiveness of PAH-A in augmenting skeletal muscle growth has not
previously been described in poultry. The ultimate goal of our study was to investigate
the effects of PAH-A on skeletal muscle production in broilers. We hypothesized that
in ovo administration of PAH-A would increase body mass gain (BMG) and muscle
fiber cross-sectional-area (CSA) of standard broilers at post-hatch days 3 (D3) and 14
(D14). |
| URI: | http://hdl.handle.net/10090/4932 |
| Appears in Collections: | Kalamazoo College Diebold Symposium
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Files in This Item:
| File |
Description |
Size | Format |
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| SniderBrittany_Diebold2008.pdf | poster presentation | 65Kb | Adobe PDF | View/Open |
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