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Washington College Biology Senior Capstone Experience >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10090/3770
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| Title: | Effects of glucocorticoids on the development of alzheimer's disease in normal aged mice |
| Authors: | Pranski, Elaine |
| Issue Date: | 18-Jan-2008 |
| Abstract: | In Alzheimer’s disease (AD), glucocorticoid levels are elevated and levels
of the enzyme responsible for glucocorticoid degradation are depressed. Shortterm
glucocorticoid exposure induces the β-Amyloid and Tau pathologies in
transgenic mice predisposed to AD (Green et al. 2006). The effects of chronic
glucocorticoid administration in aged mice (Mus domesticus) on learning and
memory were examined by the Morris water maze and β-amyloid and Tau
protein levels were monitored. Twenty C57BL/6J mice were given daily injections
of the glucocorticoid dexamethasone or a control substance for two weeks.
Dexamethasone-treated mice showed improved performance in the Morris water
maze in spite of increased APP and Tau accumulation. Tacrine, a reversible
acetylcholinesterase inhibitor, was not found to alter APP levels, but may act as a
protective agent by preventing Tau accumulation. High glucocorticoid levels may
cause increases in AD-related protein accumulations, but over the short-term,
these pathologies do not appear to result in the impairment of learning and
memory of mice. |
| Description: | A thesis submitted to the
Department of Biology
in partial fulfillment of the
requirements for the degree of
Bachelor of Science. Spring 2007 Thesis Advisor: Dr. Jeffrey Brown |
| URI: | http://hdl.handle.net/10090/3770 |
| Appears in Collections: | Washington College Biology Senior Capstone Experience
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Files in This Item:
| File |
Description |
Size | Format |
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| Pranski_BIO.pdf | | 1014Kb | Adobe PDF | View/Open |
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