http://hdl.handle.net/10090/617 Search the Channel search http://dspace.nitle.org/simple-search http://hdl.handle.net/10090/3784 Title: Ethanol as a teratogen and zebrafish development: relation to fetal alcohol syndrome <br/> <br/>Authors: Webster, Lindsey <br/> <br/>Abstract: Neural crest cells are precursors to craniofacial elements in vertebrates. In humans, multiple defects, including neurological, behavioral and morphological abnormalities have been characterized in children born to chronic alcohol drinkers. Some of these Fetal Alcohol Syndrome (FAS) related defects have been observed in other vertebrates exposed to ethanol during development. The goal of this project is to determine how ethanol exposure affects development of zebrafish neural crest derivatives. With increasing exposure to ethanol, it was suspected that zebrafish embryos would have more severe craniofacial abnormalities due to abnormal neural crest cell migration, differentiation, or cell death. Zebrafish embryos were exposed to varying concentrations of ethanol from approximately 30% epiboly until 24 hours post fertilization and development was monitored. Embryos were stained with alcian blue to observe facial cartilage after six days of development. Cartilage length and interocular distance were measured. Moderate ethanol exposure resulted in increased interocular distance while higher ethanol concentrations led to a reduction in this distance. As ethanol dose increased, the length of cartilage elements decreased. These defects are consistent with some pathologies associated with FAS and may be due to abnormal crest development. <br/> <br/>Description: A thesis submitted to the Department of Biology in partial fulfillment of the requirements for the degree of Bachelor of Science. Spring Semester 2007 Thesis Advisor: Dr. Jeffrey Brown Fri, 18 Jan 2008 19:50:00 GMT http://hdl.handle.net/10090/3782 Title: Development and evolutionary history of teeth as related to the biogenic <br/> <br/>Authors: Song, Jin <br/> <br/>Description: A thesis submitted to the Department of Biology in partial fulfillment of the requirements for the degree of Bachelor of Science. Spring Semester 2007 Thesis Advisor: Dr. Hugh Jarrard Fri, 18 Jan 2008 19:46:12 GMT http://hdl.handle.net/10090/3771 Title: Introduction of lyme disease to the human population: its history, evolution, and epidemiology <br/> <br/>Authors: Severin, Raymond S. <br/> <br/>Description: A thesis submitted to the Department of Biology in partial fulfillment of the requirements for the degree of Bachelor of Science. Spring Semester 2007 Thesis Advisor: Dr. Martin Connaughton Fri, 18 Jan 2008 15:51:03 GMT http://hdl.handle.net/10090/3770 Title: Effects of glucocorticoids on the development of alzheimer's disease in normal aged mice <br/> <br/>Authors: Pranski, Elaine <br/> <br/>Abstract: In Alzheimer&#8217;s disease (AD), glucocorticoid levels are elevated and levels of the enzyme responsible for glucocorticoid degradation are depressed. Shortterm glucocorticoid exposure induces the &#946;-Amyloid and Tau pathologies in transgenic mice predisposed to AD (Green et al. 2006). The effects of chronic glucocorticoid administration in aged mice (Mus domesticus) on learning and memory were examined by the Morris water maze and &#946;-amyloid and Tau protein levels were monitored. Twenty C57BL/6J mice were given daily injections of the glucocorticoid dexamethasone or a control substance for two weeks. Dexamethasone-treated mice showed improved performance in the Morris water maze in spite of increased APP and Tau accumulation. Tacrine, a reversible acetylcholinesterase inhibitor, was not found to alter APP levels, but may act as a protective agent by preventing Tau accumulation. High glucocorticoid levels may cause increases in AD-related protein accumulations, but over the short-term, these pathologies do not appear to result in the impairment of learning and memory of mice. <br/> <br/>Description: A thesis submitted to the Department of Biology in partial fulfillment of the requirements for the degree of Bachelor of Science. Spring 2007 Thesis Advisor: Dr. Jeffrey Brown Fri, 18 Jan 2008 15:41:01 GMT